Bullmarket French Bulldog Breeders

Mae Comes Home – with Degenerative Myelopathy

Mae makes herself at home

Mae makes herself at home

Some of you might recall Mae – she’s our big boned cream girl, also famous for being mom to the uber cute Solo. Mae was placed into a retirement home, but when things got rough for her adoptive mom, she thought it was best for Mae to come back to us. We’re always ready to take back any of our placed dogs, so of course we arranged to pick Mae Mae up.

We knew she’d been experiencing some rear end weakness, and that her vet had been having a hard time coming up with a definitive diagnosis for what was causing it. I’d assumed it was likely arthritis – her vet had speculated it was first stage degenerative disk disease, but in my (thanfully limited) experience with that, it usually comes as a ‘bolt from the blue’. One day, your dog goes to sleep completely normal, the next day, they wake up paralyzed.

Mae’s condition, on the other hand, was slowly progressive.

Knowing Mae was coming home, I made a vet appointment for the following day. Once I’d seen Mae, I was even more glad I’d made the appointment.

Mae’s hind end weakness is very pronounced – she knuckles over when she walks, and on slick surfaces she comes close to dragging her rear. She also has some difficulty bending forward to reach a water dish – an elevated feeding platform seems to have alleviated some of this.

Mae is also now fecally incontinent – she does not seem to realize when she needs to defecate, until after she’s already done so.  Basically, she’ll be walking past you, and poop will just sort of fall out of her. A few seconds later, she’ll seem to think “Oh, hey. I think I have to go outside and poop”, at which time she’ll head over to the door to ask to go outside. Pickle, who has developed the disturbing habit of poop eating, is currently regarding Mae as a kind of walking gumball machine.

Because Mae isn’t pushing when she defecates, her anal glands aren’t getting expressed, so she’s developed a rather nasty abcess. Poor baby! Nothing says ‘welcome home’ like having someone wrestle you down and clean out your butt abcess.

I realize that all of this sounds rather horrible. Mae, however, is still her happy, playful, joyful self, and she’s obviously in no pain (well, other than the butt squeezing).

I had a bad idea that I knew what all of these symptoms added up to – degenerative myelopathy. I wanted the veterinarian to help me to determine if I was right, and what the prognosis was.

Degenerative Myelopathy, for those lucky enough to have never encountered this horrid condition, is a progressive auto immune disease. It affects all dogs, of all breeds including mixes, and is thought to be similar to Lou Gehrig’s Disease in people.

The Canine Genetic Disease Network has a brief overview of DM –

Degenerative myelopathy is a progressive disease of the spinal cord in older dogs. The disease has an insidious onset typically between 8 and 14 years of age. It begins with a loss of coordination (ataxia) in the hind limbs. The affected dog will wobble when walking, knuckle over or drag the feet. This can first occur in one hind limb and then affect the other. As the disease progresses, the limbs become weak and the dog begins to buckle and has difficulty standing. The weakness gets progressively worse until the dog is unable to walk. The clinical course can range from 6 months to 1 year before dogs become paraplegic. If signs progress for a longer period of time, loss of urinary and fecal continence may occur and eventually weakness will develop in the front limbs. Another key feature of DM is that it is not a painful disease.

As you can tell, this pretty much sums up Mae’s symptoms. But what causes Degenerative Myelopathy?

Degenerative myelopathy begins with the spinal cord in the thoracic (chest) region. If we look under the microscope at that area of the cord from a dog that has died from DM, we see degeneration of the white matter of the spinal cord. The white matter contains fibers that transmit movement commands from the brain to the limbs and sensory information from the limbs to the brain.

This degeneration consists of both demyelination (stripping away the insulation of these fibers) and axonal loss (loss of the actual fibers), and interferes with the communication between the brain and limbs. Recent research has identified a mutation in a gene that confers a greatly increased risk of developing the disease.

The PNAS website has this side by side comparison view of thoracic spinal cords, showing the clinical changes which DM causes:

Side by side image of thoracic spine in DM affected and non affected dogs

Fig. 2.

Spinal cord histopathology. (A) Luxol fast blue-periodic acid Schiff staining of a thoracic spinal cord cross-section from a DM-affected 13-year-old Pembroke Welsh corgi. The white matter degeneration is depicted by regions of pallor where there has been loss of nerve fibers. (B) A similarly stained spinal cord cross section from an unaffected 13-year-old Labrador retriever. Note there is no evidence of nerve fiber loss. The bar in the lower right of the photomicrograph indicates the magnification.

Until recently, diagnosis of Degenerative Myelopathy was, in the words of the CGD website, a “diagnosis of elimination”. In other words, look for other causes, rule them out, and when you run out of options you can assume it’s DM.

Now, thankfully, we have a DNA test which can identify the genetic marker for DM (thank you, Canine Genome Project).

The DNA test is offered, free of charge, to French Bulldogs, Chesapeake Bay Retrievers,  Boxers, Pembroke Welsh Corgis and Rhodesian Ridgebacks, thanks to donations made by the AKC Canine Health Foundation, American Boxer Charitable Foundation, Pembroke Welsh Corgi Club of America, Rhodesian Ridgeback Club of the United States, French Bulldog Club of America, and French Bulldog Rescue League. However, it is only free to dogs age ten years and older. Mae doesn’t make this cut off, so we’ve ordered hers for $65.

Data is collected via OFA (Orthopedic Foundation for Animals).

When it arrives we’ll have Mae’s blood collected, and use the kit to send her samples to OFA for definitive diagnosis. This won’t help us to treat her condition – there is no treatment or cure for Degenerative Myelopathy. It will, however, allow us to help to contribute to on going research into the condition.

Mae’s prognosis isn’t great. DM is, I’ve mentioned, a progressively worsening condition. She’ll lose more and more of her co ordination, and her rear limb weakness will steadily worsen. Eventually, her rear will cease to be functional at all, at which time she’ll only be able to get around if we obtain a mobility cart for her. After a time, the paralysis will spread to her front limbs, and finally to difficulty in swallowing. Thankfully, there is no pain associated with DM.

For now, we’ll wait for a definite diagnosis, and continue to enjoy Mae’s presence. She’s happy to be here, and she really seems to enjoy once more having other dogs for company. Pickle has adopted Mae as the mommy she’s always wanted, while Delilah is fairly certain we’ve hired Mae as a live in nanny to care for that pesky kid of hers.

In other words, it’s business as usual over at Casa Bullmarket.

11 replies
  1. Jennifer
    Jennifer says:

    Poor Mae, my akita Tomo had DM, it’s hard. She is a lovely looking girl. Hoping for the best diagnosis for her.

  2. Joanna Kimball
    Joanna Kimball says:

    I am so sorry. As a Cardigan corgi breeder, I am very familiar with the research. DM is no fun.

    Just as one clarification, though, DM is not autoimmune. It used to be thought that it was, but the research found no signs of inflammation or immune response. It seems to be a disease where (for lack of a better explanation) “junk” accumulates around the nerves. The dogs who are carriers of the disease ALSO get accumulation, but it happens much more slowly and doesn’t seem to get to the point of causing symptoms. Even the vast majority of genetically at-risk dogs never show any problems. Nobody knows why some of them do.

    I hope you get some good answers for her; it’s wonderful to know that her quality of life will be excellent. Our thoughts are with you.

    • frogdogz
      frogdogz says:

      Just as one clarification, though, DM is not autoimmune. It used to be thought that it was, but the research found no signs of inflammation or immune response. It seems to be a disease where (for lack of a better explanation) “junk” accumulates around the nerves.

      Thanks for letting me know this. I’ve been giving myself a crash education in it – even my vet was really sketchy about just what, exactly, DM is (much less what causes it). Question – have you heard anything about there being a potential risk for possible DM dogs in getting a myelogram? I found a suggestion on one website that there’s some sort of unspecified risk associated with it, and I do know of one person who had a DM possible dog die on the table during a myelogram. Now, of course, I can’t find that reference site.

      I’d also love suggestions for any other good, up to date sites about DM, as well as any suggestions for possible … well, not treatments – but courses of action which can delay progression of the disease. I’ve found a few sites suggesting a link between diet and slowed progression of DM.

      As you can tell, we’re doing all we can to try to learn as much as we can about this disease. Mae, in the meantime, is just happy to have a fireplace to sleep in front of 😉

      • Joanna Kimball
        Joanna Kimball says:

        I do not know about specific risks associated with myelograms, but since that particular test is known to be very invasive and painful I would not be likely to give it if I was pretty dang sure it was DM. Dr. Coates at U Missouri (the researcher most of us would identify as the leading one right now) says that there’s not a lot that can be done except as much exercise as possible, so take any Internet “recipes” with a grain of salt, but I would personally do a B complex and vitamin E for sure, and probably MSM. I know with a Frenchie it’s an uphill battle, and you don’t want to decrease muscle mass any more than she already has, but getting her as slim as possible will help her stay upright longer as her proprioreception goes.

        I am really not up to date on DM in non-corgi breeds, but in Pems the normal course of the disease is 18 months to two years. So she can still have a LOT of very good days, especially if she can adapt to a cart. And, thank goodness, it’s painless.
        .-= Joanna Kimball´s last blog ..How to kill a shelter dog =-.

        • frogdogz
          frogdogz says:

          in Pems the normal course of the disease is 18 months to two years.

          Well, she’s at about the one year mark, so we’ll cross our fingers for at least another six months of happy Mae days. I’ve got her on strict raw, which should take the bulk of her chubbiness off. I’m sure that will help.

          One of the diets I actually found was on the U Florida site – I’m going to dig it up and post it.

  3. Cait
    Cait says:

    Poor Mae!

    BUT, if it helps? A lot of corgis live long full lives with DM – carts help, and dogs DO adapt. It’s not GOOD- but it’s not an instant death sentence, either- and well.. I can think of things I’d rather a dog not have if it meant having DM instead, which is pretty much painless.
    .-= Cait´s last blog ..Someday I’ll get better about updating. =-.

  4. Kanawwuth Tang
    Kanawwuth Tang says:

    Dear seller
    She so beautiful
    I like her
    I am stay in Bangkok Thailand
    Price and ship in my country ?
    Best Regards

  5. Susie
    Susie says:

    Oh hi Mae! Please stay here. You’re too pretty to be shipped to the Far East. 🙂 At any price.

    I am sad and sorry to hear of your illness, however, I am dearly heartened to learn that you have once again found yourself in the house with lots of friends and family and tasty meals. I know Pickle is glad you’re there. Weezie would like that, too. I’ll be thinking about you.

    xo Susie

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